How long does XANAX stay in your system, Blood, Urine (Alprazolam)

Xanax, known as alprazolam, belongs to the class of benzodiazepines that affect the central nervous system and helps reduce stress to make us calm. You may be wondering how long does Xanax stay in your system, blood, hair and last in your urine if you are new to consume it. keep reading to know about different doses (mg) for different patients.

It works by acting on gamma-aminobutyric acid (GABA) – a neurotransmitter in the brain. Xanax was discovered by Pfizer and was approved by the Food and Drug Administration in 1981. It is used for generalized anxiety disorder (GAD), anxiety-related depression and panic disorders. Besides, it is also utilized in the treatment of depression and premenstrual syndrome (PMS).

How long does Xanax stay in your system and blood?

How long does XANAX stay in your system

As mentioned above, Xanax increases the transmission of gamma-aminobutyric (GABA) by binding to specific benzodiazepine receptors. In the body, GABA also significantly inhibits the propagation of many essential substances such as noradrenaline, serotonin, dopamine, and acetylcholine. Let’s talk about how long does Xanax stay in your system to make you calm.

After taking a dose, it is well absorbed in the gastrointestinal tract and achieves the peak plasma concentration within 1 to 2 hours. Plasma half-lives of Xanax averages 11 to 15 hours.

This does is mainly metabolized by hepatic oxidation to produce the primary metabolites, alpha-hydroxy, and 4-hydroxyl alprazolam. Both substances have lower benzodiazepine receptor affinity than Xanax, and their plasma concentration is also lower than 10% Xanax. In plasma, the concentration of 4-hydroxyl alprazolam is greater than alpha-hydroxyl; however, in urine, the alpha-hydroxy content is much higher than 4-hydroxy alprazolam. It may be due to the in vitro plasma instability of the 4-hydroxyl alprazolam derivative.

The oral bioavailability of the drug is 88 ± 16%. Normal renal excretion is 20% of the dose. The mean clearance is 0.74 ± 0.14 ml/ min/ kg. The clearance is primarily through metabolism catalyzed by cytochrome P450 3A4 and P450 2D6. Thus, metabolic clearance decreased in people with obesity, cirrhosis or the elderly. The average volume of distribution is 0.72 ± 0.12 liters/ kg, so half-life elimination increases in these people. it concentration is effective in the range of 20 to 40 nanogram/ ml. To relieve panic attacks immediately, higher Xanax plasma concentration may be required.

Note: how long does Xanax last in your system will depend on how much quantity you take. if you are taking normally it will last in your urine 3 to 4 days and may be up to 300 days in your hair 

Read: psychological facts about human behavior

In this chart, you can see it is most common drug in the U.S

Xanax Chart

How are doses used for different patients?

Now if you understood how long does Xanax stay in your system, keep in mind of form and content of the dose at first. It is an oral medication including three forms with its content as follows.

  • Extended-release tablets: 0.5 mg, 1 mg, 2 mg and 3 mg.
  • Immediate-release tablets: 0,25 mg, 0.5 mg and 1 mg.
  • Disintegrating tablets: 0.25 mg, 0.5 mg, 1 mg and 2 mg.
  • Concentrated solution: 0.75 mg/ ml and 1 mg/ ml.
  1. Adult patients

To treat anxiety, the usual dose can be immediate-release tablets, disintegrating tablets or concentrated solution.

  • Initial dose: the patient takes 0.25 to 0.5 mg orally three times a day. This dosage may be increased gradually every 3 to 4 days if needed.
  • Maintenance dose: the patient takes maximum daily dose up to 4 mg orally, divided into small doses on a day.

To treat panic disorder, the usual dose can be immediate-release tablets and disintegrating tablets.

  • Initial dose: the patient takes 0.5 mg orally three times a day. This dosage may be increased gradually every 3 to 4 days if needed.
  • Maintenance dose: the patient takes 5 to 6 mg orally, divided into small doses on a day.

Besides, the patient can also take extended-release tablets with the usual dose in the following.

  • Initial dose: the patient takes 0.5 to 1 mg orally once a day. This dosage may be increased gradually no more than 1 mg every 3 to 4 days if needed.
  • Maintenance dose: the patient takes 1 to 10 mg once a day.
  • Average dose: the patient takes 3 to 6 mg once a day.

Read: Dealing with exam stress

To treat depression, the usual dose can be immediate-release tablets, disintegrating tablets or concentrated solution.

  • Initial dose: the patient takes 0.5 mg orally three times a day. This dosage may be increased gradually no greater than 1 mg every 3 to 4 days.
  • Average dose: the patient takes 3 mg orally per day, divided into multiple doses.
  • Maximum dose: the patient takes maximum dose up to 4.5 mg per day, divided multiple doses.
  1. Elderly patients

To treat anxiety, the usual dose can be immediate-release tablets, disintegrating tablets or concentrated solution.

  • Initial dose: the elderly patient takes 0.25 orally twice or three times a day. This dosage may be increased gradually if necessary.

The elderly patients are sensitive to benzodiazepines so they should use the usual dose no more than 2 mg.

To treat panic disorder, the usual dose can be immediate-release and disintegrating tablets.

  • Initial dose: the elderly patient takes 0.25 orally twice or three times a day. This dosage may be increased gradually every 3 to 4 days if necessary.
  • Besides, the patient can also take extended-release tablets with the usual dose in the following.
  • Initial dose: the patient takes 0.5 mg orally once a day, in the morning if possible. This dosage may be increased gradually if necessary.

To treat depression, the usual dose can be disintegrating tablets and concentrated solution.

  • Initial dose: the elderly patient takes 0.25 orally twice or three times a day. This dosage may be increased gradually if necessary.

The elderly patients are sensitive to benzodiazepines so they should use the usual dose no more than 2 mg.

  1. Young patients

The dose for children has not been studied and decided. Ask your doctor if you plan to use this medicine for your baby.

What should you know before taking Xanax?

  1. When you are pregnant, you should not take it because it can harm the fetus. Besides, it can also cause symptoms of addiction in a newborn if you use it during pregnancy.
  2. It can enter breast milk and can be harmful to your baby. Do not breastfeed your baby while using this medication.
  3. Do not take it, if you are using itraconazole (Sporanox) or ketoconazole (Nizoral).
  4. Do not take it if you have an allergy to it or other types of benzodiazepines.
  5. Consult with your doctor before taking this drug if you have respiratory problems, glaucoma, disease related to kidney or liver, or you used to have depression or addiction to heroin or alcohol.
  6. As now you know how long does Xanax stay in your system so this amount of time can make you completely relax.

How should you take Xanax?

  1. Take it exactly as prescribed by your doctor. Sometimes, the doctor may change the dose to ensure the best result.
  2. Swallow whole pills instead of breaking them into small pieces so that they can release the drug slowly into the body. Breakage is causing too many drugs issuing at the same time.
  3. Tell your physician if Xanax appears to be ineffective in your treatment.
  4. There may be seizures or symptoms of addiction when stopping it. Ask your doctor how to avoid these symptoms when stopping it.
  5. Store it at the room temperature.

See also: what is Mental illness

What should you avoid when taking Xanax?

    1. Do not consume alcohol while taking Xanax. It can increase the impacts of alcohol.
    2. it can reduce thought or reaction. Watch out if you do anything that requires concentration.
    3. Do not use pomelo products while you are taking it. The reason is that they may have interaction with Xanax and result in possibly poor impacts.

What will happen if you forget a dose of Xanax? 

Take that dose immediately when you recall. Skip the missed dose if it is close to the time for the next dose. Do not take double dose including the forgotten dose at the same time.

What will happen if you take an overdose of Xanax?

Seek medical attention urgently. Overdosing can cause symptoms such as balance loss, fainting, confusion, muscle weakness, extreme drowsiness, and lethargy. More dangerously, it may cause death for patients.

Share this article how long does Xanax last in your system and let us know your thoughts about this post by commenting below

 

REFERENCE:

https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0008896/

 

JASMINE HE

Being interested in health and beauty as well as having a strong desire for the well-being, I have a broad knowledge of this area after having the patience to learn and experience it for a couple of years. Along with my current education job, I have now been working as a freelance writer on health and beauty.

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16 Responses

  1. Nikol says:

    6 years ago, following a big shock, in full depression, a sorcerer’s apprentice put me under xanax (only 0.5) and I was a zombie !!

    I was more anxious than before, I was shaking, I was cold and I was missing !!

    I am not “for” this type of medication and I react quickly to a so-called alternative medicine that has no side effects …

    try to take abundant magnesium that will have the effect of you to find calm and sleep, which will soothe you and make you happy!
    there is also “stress bioptimum” which is good but is not refunded !!

    I’m just going to say a little thing that will probably not please you, but never mind, it’s like this: if your xanax delay, effexor exel, steelnox, lormetazepam and other horrors were not reimbursed, how would you? !

    if you had to PAY yourself to drug yourself, did you go on ?!

    think about it and it will probably help you to let go … because that’s what it is, the “let go” !!

  2. anie says:

    I am 29 years old and have been taking alprazolam under medical supervision, of course, for almost two and a half years. I went from a very high dose (4 to 5 mg / day) to 1 mg / day currently. I can not currently go below this dose because I have physical symptoms of lack (nausea, internal tremor, feeling of emptiness and violent anguish). My initial diagnosis was: several features of borderline personality disorder and dysmorphophobia. I took a group therapy for borderline that helped me a lot.For the medication,
    it was not easy because I can not stand any neuroleptic (violent panic attacks) and prozac and other antidepressants or regulators of mood make me look like a glass of water. Only the benzo acted positively on me, the xanax in the occurrence, last resort doctors because of the dependence it generates … But with the alprazolam, while continuing my therapy, I’m getting better and better. Around me, I hear only contradictions, some demonize the benzo, saying that “it is much worse than the joints and even that the coke, that the doctors exploit us like guinea pigs to advance in their science”, etc. Others, on the contrary, think that at a small dose, it suits me very well and that I am making immense progress in my behavior.
    -Do you think that I can stop one day, or will I continue to take all my life, or for many years anyway, as my doctor insinuates?
    -Is there any real health hazards to consume 1 mg xanax per day over a long period?

  3. kathy says:

    The real question is whether you really need it right now and how you would be without …
    Treatment is always a compromise, we do not take it for pleasure.
    I took Lexomil in high doses for several years, which certainly had huge drawbacks, but if I had not taken it, given the state of completely destructuring anxiety in which I was, I am I’m not sure I’ll be here to talk about it. And I was finally able to stop, but also because I had other means of treatment, including intense psychotherapeutic work …
    It is up to you, in agreement with your doctor, to see what is best for you at every step of your evolution. Nothing is fixed, and the treatment is only to help us move forward, it’s not an end in itself …
    Finally, do not listen too much to the bad sirens. Doctors who take us for guinea pigs, there may be, but I have never known (and I know a number
    ), I imagine that yours adapts your treatment to the best of what he thinks it’s valid for you right now.
    The worst way to take a treatment, and not enjoy it, is to feel guilty about taking it! Take it for what it is: a tool at your service, nothing more.

  4. LIli says:

    I cannot live without my xanax. I needed it when I woke up. I needed it because I could not get out of my house. sometimes I just took it because I felt a lack. my psychiatrist gave me at will. I took up to 6×0.50 at a time or 8×0.50 / day. it lasted 6 years.

    and overnight, everything is stopped. I no longer need. I did not understand what a miracle, but it’s like that. all the better, I will not complain 🙂

  5. Ela says:

    I’m also panic attacks with agoraphobia. But they are less violent than before I control them better. Before I took lexomil but I had anyway very violent panic attacks with so I stopped everything; My doctor prescribed me xanax is better said he but I never took it, I still have it in my bag to reassure me in case.
    I am very afraid to take medication, fear of addiction and side effects so I control my attacks with the will but sometimes it is not easy but little by little I get there because I know the symptoms and I’m not afraid anymore. If you want some advice I’m on the site daily (maybe because I still need to have testimonials for some reassurance

  6. freya says:

    I do not know if alprazolam is toxic, moreover, I can only imagine its metabolites (I am a chemist). My own benzo is given 200 mg / day for the withdrawal of morphine and heroin. It was given 10 mg / hour or 240 mg / day at the first one saved tetanus which certainly was in an artificial coma. I have taken 300 mg / day three days in a row. I think that my addiction episodes are too short (15 days to 1 month) for physical dependence to develop. I have no effect on memory. My psychiatrist does not reject the idea that these episodes cover violent manic episodes.

  7. Anon says:

    Hello ;

    1) I have been in depression for 3 years and I take Effexor exel 150 (in the morning) as well as Xanax delay 1Mg (in the evening). The problem is that at each waking I have a “ball” in the stomach, a fear, anguish (call it what you want) and then I have to take xanax 0.75mg drop to calm that feeling. 🙁
    Does anyone live the same thing?
    2) My psychiatrist advised me to stop Xanax late in the evening because apparently it does not make me any more effective and prescribed me the Victan 2Mg (You know?), But I just stopped my xanax for a day that I already have vertigo, so my question is: is there a (severe) dependence on xanax and how long I would be weaned : ??:
    3) I also take sleeping pills, either Stilnoct 10Mg or Lormetazepam 2Mg, because I sleep very badly.

    So, if you can help me, advise me or tell me more about these drugs, it would be great 🙂

    Thank you all.

  8. pal J says:

    hello Anon, I will try to help you, because I also take effexor and xanax, and this, for 12 years, it’s true that I can not do without it because I’m too bad, but like that I’m fine, I do not want to be bad, in the evening I take effexor delay 75 mg, and xanax 1 mg, the morning I’m good and a good day in front of me, I hope I could help you a few, kisses sincerely, .

  9. alex says:

    i take xanax before going to exam to relax myself.

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